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KMID : 0381120170390050541
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Genes and Genomics
2017 Volume.39 No. 5 p.541 ~ p.548
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Identification of genetic loci associated with abdominal visceral adiposity in Korean populations
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Hong Jin-Tae
Cho Yoon-Shin
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Abstract
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Abdominal obesity is characterized by accumulation of subcutaneous and visceral fat in the abdomen and has been reported to be largely responsible for many metabolic and vascular diseases. Although substantial effort has been dedicated to identification of genetic factors associated with abdominal obesity, as measured by the waist-hip ratio and waist circumference, only a few studies have explored associations with visceral fat accumulation in the abdomen. Furthermore, genetic studies of abdominal visceral adiposity conducted in Asian ethnic groups are rare. To gain insight into the genetic basis for visceral adiposity in Asian subjects, we conducted genome-wide association analysis for a pool of 1594 Korean subjects. Abdominal visceral fat area was estimated by computed tomography. After adjustment for age, linear association analysis identified three loci showing suggestive evidence of association (P?
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KEYWORD
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Abdominal obesity, Visceral adiposity, Computed tomography, Genome-wide association study, Genetic risk score
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